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Rommelfanger SR, Zhou M, Shaghasi H, Tzeng SC, Evans BS, Paša-Tolić L, Umen JG, Pesavento JJ. Rommelfanger SR, et al. J Am Soc Mass Spectrom. 2021 Jul 7;32(7):1671-1688. doi: 10.1021/jasms.1c00029. Epub 2021 Jun 24. J Am Soc Mass Spectrom. 2021. PMID: 34165968 Free PMC article.

Our A Level Chemistry B (Salters) qualification engages students by presenting chemical ideas and practical skills in a variety of contexts, relating modern-day applications of chemistry and current research to the concepts needed for the study of chemistry at A Level. Maryam S, Khan MR, Shah SA, Zahra Z, Batool R, Zai JA. Maryam S, et al. J Ethnopharmacol. 2019 Jun 28;238:111849. doi: 10.1016/j.jep.2019.111849. Epub 2019 Apr 4. J Ethnopharmacol. 2019. PMID: 30953822 The story of the three-part OVA has Chise already somewhat settled into her life with the magical, skull-headed Elias. She finds a book titled The Lonely Little Star, which reminds her of her troubled life before meeting him. From there, she finds a magical library in the forest and becomes entangled in the machinations of the magician that maintains it.This review summarizes genetic, molecular and biochemical studies of the SU(VAR)3-9 protein and the evidence for its key role in heterochromatin formation and heterochromatic gene silencing. The Su(var)3-9 locus was first identified as a dominant modifier of position-effect variegation (PEV) in Drosophila melanogaster. Together with Su(var)2-5 and Su(var)3-7, Su(var)3-9 belongs to the group of haplo-suppressor loci which show a triplo-dependent enhancer effect. All three genes encode heterochromatin-associated proteins. Su(var)3-9 is epistatic to the PEV modifier effects of Su(var)2-5 and Su(var)3-7, and it also dominates the effect of the Y chromosome on PEV. These genetic data support a central role of the SU(VAR)3-9 protein in heterochromatic gene silencing, one that is correlated with its activity as a histone H3-K9 methyltransferase (HMTase). In fact, SU(VAR)3-9 is the main chromocenter-specific HMTase of Drosophila. SU(VAR)3-9 and HP1, the product of Su(var)2-5, are main constituents of heterochromatin protein complexes and the interaction between these two proteins is interdependent. Functional analysis in fission yeast, Drosophila and mammals demonstrate that SU(VAR)3-9-dependent gene silencing processes are conserved in these organisms. This is also demonstrated by the rescue of Drosophila Su(var)3-9 mutant phenotypes with human SUV39H1 transgenes. Schotta G, Ebert A, Krauss V, Fischer A, Hoffmann J, Rea S, Jenuwein T, Dorn R, Reuter G. Schotta G, et al. EMBO J. 2002 Mar 1;21(5):1121-31. doi: 10.1093/emboj/21.5.1121. EMBO J. 2002. PMID: 11867540 Free PMC article.

Though The Ancient Magus' Bride: Those Awaiting a Star is billed as a prequel to the show, a more accurate term would be "interquel." Its events roughly fall in place with the middle of the series, approximately around episodes 12-13. These episodes reflect on Chise's past, her parents and her growing relationship with Elias. The OVA thematically matches these elements, and are far too related to them to be a true prequel.

Our AS Level Chemistry B (Salters) qualification engages students by presenting chemical ideas and practical skills in a variety of contexts, relating modern-day applications of chemistry and current research to the concepts needed for the study of chemistry at AS Level. Ebert A, Schotta G, Lein S, Kubicek S, Krauss V, Jenuwein T, Reuter G. Ebert A, et al. Genes Dev. 2004 Dec 1;18(23):2973-83. doi: 10.1101/gad.323004. Genes Dev. 2004. PMID: 15574598 Free PMC article.

da Silva ÉR, Salmazzo GR, da Silva Arrigo J, Oliveira RJ, Kassuya CA, Cardoso CA. da Silva ÉR, et al. Inflammation. 2016 Aug;39(4):1462-8. doi: 10.1007/s10753-016-0378-3. Inflammation. 2016. PMID: 27271512 Bughio FJ, Maggert KA. Bughio FJ, et al. Proc Natl Acad Sci U S A. 2022 Jun 21;119(25):e2118796119. doi: 10.1073/pnas.2118796119. Epub 2022 Jun 15. Proc Natl Acad Sci U S A. 2022. PMID: 35704756 Free PMC article.Khlifi A, Pecio Ł, Lobo JC, Melo D, Ben Ayache S, Flamini G, Oliveira MBPP, Oleszek W, Achour L. Khlifi A, et al. J Ethnopharmacol. 2021 Apr 6;269:113739. doi: 10.1016/j.jep.2020.113739. Epub 2021 Jan 12. J Ethnopharmacol. 2021. PMID: 33359854 Kolesnikova TD, Klenov MS, Nokhova AR, Lavrov SA, Pokholkova GV, Schubert V, Maltseva SV, Cook KR, Dixon MJ, Zhimulev IF. Kolesnikova TD, et al. Cells. 2022 Dec 1;11(23):3872. doi: 10.3390/cells11233872. Cells. 2022. PMID: 36497131 Free PMC article.

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